This article systematically analyzes the antibiotic resistance patterns of Vibrio mimicus (Vm) isolated from seafood and aquatic environments, revealing its high resistance rates to multiple antibiotics globally, particularly more pronounced in Asian and African regions. Using the Antibiotic Resistance Risk Index (ARRI) for assessment, the study finds that Vm resistance burden in seafood and aquatic environments is significantly higher than in human clinical samples, emphasizing the role of aquatic products and environments as critical vectors for resistance transmission.
Literature Overview
This article, titled 'Occurrence and Antibiotic Resistance Risk Burden of Vibrio mimicus Isolates from Seafood and Aquatic Environments' and published in the journal Antibiotics, reviews and summarizes antibiotic resistance data of Vibrio mimicus isolated from seafood and aquatic environments, assessing antibiotic resistance risk indices across different global regions. The study reveals high resistance of Vm to various commonly used antibiotics in clinical settings and highlights the significance of Asian and African regions as resistance hotspots. The content is coherent and logically structured.
Background Knowledge
Vibrio mimicus is a marine and freshwater bacterium similar to Vibrio cholerae, capable of causing cholera-like gastroenteritis but typically lacking cholera toxin. Nevertheless, it can carry multiple virulence factors leading to severe illness. In recent years, the issue of antibiotic resistance in Vm has become increasingly prominent due to the widespread use of antibiotics in aquaculture. Resistance genes can spread through horizontal gene transfer in the environment, increasing the difficulty of treating human infections. This article systematically analyzes the antibiotic resistance of Vm strains isolated from seafood and aquatic environments, with particular focus on multidrug resistance and the Antibiotic Resistance Risk Index (ARRI). The study finds that Vm exhibits high resistance to penicillins, cephalosporins, macrolides, and polymyxins, while resistance to carbapenems and certain fluoroquinolones is lower. Additionally, the research identifies Asia and Africa as resistance hotspots for Vm, emphasizing the need to strengthen One Health monitoring strategies to control the spread of resistance.
Research Methods and Experiments
The research team compiled antibiotic resistance data from 423 Vm isolates across 19 studies using systematic review and meta-analysis methods, covering samples from seafood, environmental water, and clinical sources. A random-effects model was employed to evaluate resistance across different sample types, and the Antibiotic Resistance Risk Index (ARRI) was calculated to compare resistance burdens across sources and geographic regions.
Key Conclusions and Perspectives
Research Significance and Prospects
This study provides a systematic evaluation of the global distribution of Vm antibiotic resistance, highlighting the critical role of seafood and aquatic environments in resistance dissemination. Future efforts should focus on enhancing regional resistance monitoring, optimizing antibiotic use policies, and exploring alternative antimicrobial strategies (e.g., phage therapy, probiotics) to reduce antibiotic dependence. Furthermore, genomic analyses should be prioritized to identify mechanisms of horizontal gene transfer of resistance genes, ensuring the continued effectiveness of clinical treatment approaches.
Conclusion
This article systematically examines the antibiotic resistance distribution of Vibrio mimicus in seafood and aquatic environments, revealing high resistance to multiple antibiotics, especially in Asian and African regions. The study emphasizes the role of aquatic products and environments as key transmission routes for antibiotic resistance and recommends measures such as enhanced antibiotic regulation, improved wastewater treatment, and the adoption of One Health strategies to reduce resistance spread. Additionally, clinicians and researchers are advised to monitor multidrug resistance in Vm to avoid failures in empirical antibiotic therapy. Future research should focus on the mechanisms of horizontal gene transfer of resistance genes and develop alternative antimicrobial interventions to reduce reliance on antibiotics.
