This paper systematically analyzes the impact of different farming practices on the migration and persistence of manure-derived antibiotic resistance genes (ARGs), proposes integrated management strategies to reduce ARG pollution in agriculture, and provides scientific support for sustainable agricultural development and public health security.
Literature Overview
This paper titled 'Exploring the Relationship Between Farmland Management and Manure-Derived Antibiotic Resistance Genes and Their Prevention and Control Strategies' was published in the journal 'Antibiotics'. It reviews and summarizes how farming practices (conventional tillage versus conservation tillage) influence the migration, persistence, and spread risk of antibiotic resistance genes (ARGs) from manure in agricultural soils. The paper systematically analyzes the regulatory mechanisms of different tillage systems on ARG distribution and proposes integrated management strategies to reduce ARG diffusion in agricultural environments. The entire paragraph is coherent and logical, ending with a period in Chinese.
Background Knowledge
Antibiotic resistance genes (ARGs) are widely present in livestock manure, particularly in swine, poultry, and cattle waste, and their types encompass nearly all clinically important antibiotics. These resistance genes enter agricultural fields via manure application, becoming a significant source of soil microbial resistance gene pools. Conventional tillage (CT) and conservation tillage (e.g., no-till, reduced till) have significant impacts on the distribution, vertical migration, horizontal gene transfer, and persistence of resistance genes in soils. Agricultural management practices such as soil texture, fertilization methods, and crop rotation systems further influence the migration pathways of resistance genes. Currently, the comprehensive impact of farming management strategies and manure treatment methods on ARG spread has not been fully elucidated, especially how long-term tillage and fertilization reshape soil microbial networks and suppress ARG diffusion remains a research hotspot. This paper provides systematic analysis and management recommendations by synthesizing existing research, aiming to offer scientific evidence for controlling antibiotic resistance gene pollution in agriculture.
Research Methods and Experiments
This review systematically analyzes existing research to explore the impact of conventional tillage (CT) and conservation tillage (e.g., no-till [NT], reduced tillage [RT]) on the migration, persistence, and spread risk of antibiotic resistance genes (ARGs) from manure in agricultural soils. By integrating soil physicochemical properties, microbial community dynamics, and gene transfer mechanisms, the study assesses the distribution patterns of resistance genes within soil profiles under different tillage systems and their interactions with microbial ecosystems. Additionally, it analyzes the effects of fertilization management (e.g., organic versus chemical fertilizers), manure types (swine, poultry, cattle dung), and soil types (clay versus sandy soil) on the accumulation and dissemination of ARGs. The paper also evaluates the long-term impacts of tillage and fertilization on soil microbial communities, horizontal gene transfer (HGT), and ARG stability.
Key Conclusions and Perspectives
Research Significance and Prospects
This study provides a systematic framework for controlling ARG pollution in agricultural fields, highlighting the synergistic effects of tillage practices and fertilization management. Future research should further explore microbial community dynamics, horizontal gene transfer mechanisms, and the combined influence of environmental factors on ARG dissemination to develop more effective agricultural management strategies.
Conclusion
This paper systematically examines the influence of agricultural tillage and manure management on ARG spread, highlighting that conservation tillage (e.g., no-till) may increase ARG accumulation in surface soils while reducing soil erosion. In contrast, conventional tillage reduces surface gene concentrations through vertical mixing and dilution but can degrade soil structure over time. Fertilization methods and soil texture significantly affect ARG migration and persistence. Integrated management strategies, including precision agriculture, optimized fertilization, and microbial regulation, are proposed to mitigate ARG contamination risks in agricultural systems. This research provides scientific evidence and management recommendations for controlling ARGs in agricultural environments, which is of significant importance in addressing the global antibiotic resistance crisis.
